DESCRIPTION

BENEFITS

Key factor in several key biological pathways, including methylation reactions, glutathione formation and glutathione-s-transferase activity12

Complexed with disulfate tosylate, a well-tolerated, stable and clinically tested form

Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption

200 mg SAMe per tablet, allows for flexible dose titration

Sourced from the highest quality Italian Isoactive SAMe available on the market

Isoactive SAMe uses a natural fermentation process that yields 40% higher active ingredients over synthetic variations

Suitable for vegetarians/vegans

INGREDIENTS
Medicinal Ingredients
Serving Size: 1 Enteric Coated Tablet
Servings Per Container: 30
Each Tablet Contains:
S-Adenosyl-L-Methionine (SAMe)....................................200 mg

Non-Medicinal Ingredients
Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, talc, triethyl citrate, glyceryl palmitostearate, silica, titanium dioxide, medium chain triglycerides, yellow iron oxide), glyceryl behenate, vegetable grade magnesium stearate (lubricant), silica, sodium starch glycolate.

Allergens:
Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

RECOMMENDED USE

Recommended Adult Dose: SAMe should always be taken on an empty stomach.

For mood balance: 1–4 tablets 2 times per day or as directed by a health care practitioner.

For osteoarthritic pain: 1–3 tablets 2 times per day or as directed by a health care practitioner. Do not exceed a total of 8 tablets per day. SAMe must be taken for a minimum of 2 weeks, at which time effects should be observed.

WARNINGS
If you are taking antidepressants, hepatotoxic drugs or monoamine oxidase (MAO) inhibitors, consult a health care practitioner prior to taking SAMe in place of or in addition to those medications. Not recommended for use in children. Do not use if you are pregnant or breastfeeding. Do not take at night as SAMe may cause anxiety, restlessness and insomnia. People with bipolar disorder (manic-depressive illness) should not use SAMe unless under medical supervision. Possible side effects are: mild gastrointestinal upsets (such as stomach pain, nausea, diarrhea, flatulence), anxiety, hyperactive muscle movement, insomnia and hypomania. When these side effects occur they often diminish with time or resolve with lower doses or cessation of use. There are no documented cases of allergies to SAMe. Keep out of reach of children.

Drug Interactions
Deficiency of vitamins B6, B12, and other methyl donors may exacerbate SAMe deficiency. Theoretically may have additive serotonergic effects when used with antidepressants, but this has not been observed clinically, and when used simultaneously, no increase in adverse effects were noted compared to placebo