DESCRIPTION

BENEFITS

Sublingual tablets provide consistent melatonin bioavailability - pharmacokinetic studies indicate that 30 to 60% of an oral dose of melatonin is metabolized via the liver9 and overall gastrointestinal absorption is variable

A singular high potency sublingual tablet is optimal for those who need higher doses of melatonin (10-20 mg)

Derived from non-animal sources

Refreshing, natural peppermint flavour

INGREDIENTS

Medicinal Ingredients

Serving Size: 1 Sublingual Tablet

Servings per Container: 180

Each Tablet Contains:

Melatonin (Vegetarian Source)............................................10 mg

Non-Medicinal Ingredients

Lactose monohydrate, microcrystalline cellulose, natural peppermint flavour, croscarmellose sodium, vegetable grade magnesium stearate (lubricant).

Allergens:

Contains no artificial preservatives, colours or sweeteners and no soy, wheat or yeast. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

RECOMMENDED USE

Dissolve 1 tablet under the tongue at bedtime once per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 4 weeks.

WARNINGS

Consult a health care practitioner prior to use if you have a hormonal disorder, diabetes, liver or kidney disease, cerebral palsy, seizure disorders, migraine, depression and/or hypertension, or if you are taking blood pressure or sedative/hypnotic medications. Do not use if you are taking immunosuppressive drugs and/or if you are pregnant or breastfeeding. Do not drive or use machinery for 5 hours after taking melatonin. If symptoms persist continuously for more than 4 weeks (chronic insomnia), consult your health care practitioner.12 Keep out of reach of children.

Drug Interactions

Melatonin can stimulate immune function and may reduce the efficacy of immunosuppressive drugs.13 Theoretically, concomitant use of melatonin with sedative/hypnotic or central nervous system depressants may be additive. However, benzodiazepines may also reduce endogenous melatonin levels.14 Melatonin can reduce the efficacy of blood pressure medication nifedipine GITS (Procardia XL).15 Case reports suggests melatonin may potentiate anticoagulant and antiplatelet medications, however, the mechanism and clinical significance are unknown.16 Melatonin may impair glucose utilization and increase insulin resistance in diabetic patients. However, the clinical significance of this effect on diabetics is unknown.17 Contraceptive drugs can increase endogenous melatonin levels. Theoretically, this may increase the effects and adverse effects of oral melatonin use.18 Fluvoxamine significantly inhibits the elimination of melatonin,19 which some researchers believe could be helpful in the treatment of refractive insomnia.20 However, this interaction may also cause excessive unwanted drowsiness and other adverse effects.