SAMe 400 is s-adenosyl-L-methionine (SAMe) a key biological factor that drives a wide variety of essential biochemical reactions including the methylation of DNA catecholamine neurotransmitters (brain messenger-molecules) phospholipids hormones and chondrocytes (cartilage-forming cells). Research supports SAMe's ability to support healthy mood function and helps relieve osteoarthritic pain. A Key Methyl Donor for Detoxification Mood and Overall Health - Boosts mood and emotional well-being - Relieves symptoms of osteoarthritis - Provides an effective dosage and a stable form of SAMe - Promotes methylation Amount: 1 Tablet SAMe Disulfate Tosylate 800mg Ionic SAMe 400 mg Non-medicinal ingredients: microcrystalline cellulose magnesium stearate stearic acid magnesium hydroxide calcium chloride silica calcium oxide talc shellac arginine glycerol sodium alginate. Suggested Use: (Adult): Take 2 or 3 tablets daily on an empty stomach or as directed by a qualified health care practitioner. Use for a minimum of 4 weeks to see beneficial effects for osteoarthritic pain and a minimum of 2 weeks for mood support. Cautions : Do not take at night since this product may cause anxiety restlessness and insomnia. Consult a health care practitioner prior to use if you are pregnant or breastfeeding suffer from depression or are taking medications which may influence serotonin levels (e.g. antidepressants).